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They did not validate every use promoted online or establish standardized FDA-approved dosing, safety, or effectiveness for those substances

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Mangostin-coated Hap granules in a dose-dependent manner (0.05 and 0.1 mg/mL of Mangosteen extract) decreased the growth of bacteria during 24 h, reaching 99.99% bacterial diminution without any toxicity against calvaria-derived pre-osteoblastic (MC3T3-E1) cells and calcium deposition [41]